Tuesday 11 November 2008

NMR

A variety of NMR approaches can be used to detect and quantify binding of fragments to their targets.

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Stockman & Dalvit, NMR screening techniques in drug discovery and drug design. Prog. NMR Spec. 2002, 41, 187-231. DOI

Dalvit et al, WaterLOGSY as a method for primary NMR screening: Practical aspects and range of applicability, J. Biomol. NMR 2001, 21, 349-359 DOI

Fielding, Determination of association constants (Ka) from solution NMR data, Tetrahedron 2000, 56, 6151-6170 DOI

Shuker et al, Discovering High-Affinity Ligands for Proteins: SAR by NMR, Science 1996, 274, 1531-1534 DOI

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